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Tripeptidecopper complex GHK-Cu (II) transiently improved healing outcome in a rat model of ACL reconstruction

So obesity increases inflammation, increases adipose tissue malfunction, which in turn increases insulin resistance, and therefore adding up to this cycle

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Therefore, induction of HO-1 may activate AMPK pathway by enhancing the phosphorylation, thereby improving energy metabolism in cardiomyocytes [105, 106]

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